Remember, folks, wheels that pop off are only fun on toys. I've done something like this not once, but twice. The first time I forgot to tighten the lug nuts on a front wheel, which "did in" my original silver Spider back in 1996. $750 worth of frame damage = Great Parts Bin in the Sky. Best thing that ever happened to that rust bucket. I can only imagine the damage when all 4 come loose at once.
The second time was a back wheel on our present (much much nicer) Spider, back in 2004. Fortunately, all it did was rattle; it didn't come loose, and I have no idea why. On that day, when I got back and discovered what happened, God and I called it even, and we've stayed that way ever since.
And now I have helpers who always ask me if I've tightened the lug nuts BEFORE I drive away after a project.