Just in time for critical flight testing, a former Boeing engineer is claiming the company's newest product, the 787, is unsafe to fly. Unfortunately I've been cut off from my main source of inside info, Aviation Week and Space Technology, due to a subscription lapse, so I don't have the absolute latest on the program. However, such issues, especially regarding the fire safety of the fuselage, could have been (and therefore almost certainly were) investigated and addressed very early in the design phase.
The claims of toxic smoke seem to me particularly weak, as in an airplane fire it's my understanding the contents of the fuselage will be the primary contributor to smoke, and those are essentially the same no matter what the plane is made of.
Boeing is definitely taking any number of risks in the creation of their latest passenger aircraft. However, these involve things like production schedules, profit margins, and delivery dates, not basic safety. If it gets certified, I'd have no problem riding in one.