Scientists are now reporting the creation of a sheep that's 40% human on the cellular level. The goal is to create animals that will provide perfect transplant organs for patients. While the "Frankenstein-in-fleece" creep factor looms large, I think the real concern will be for cross-species disease transfer. Critics are already bringing this up, but considering the value of a transplanted organ, it would seem to me an engineering problem to create an environment which would keep these sorts of sheep completely disease-free.